Wales travel to Murrayfield on a six-day turnaround following their opening round success against Ireland.
Wales have named the same front-five that featured last weekend with Wyn Jones, Ken Owens and Tomas Francis forming the front-row.
Adam Beard continues to partner captain Alun Wyn Jones in the second row.
Aaron Wainwright comes into the back row to line up alongside Justin Tipuric and Taulupe Faletau. Both Josh Navidi and Josh Macleod are unavailable due to injury, with the latter originally selected to earn his first cap at blindside flanker before being ruled out.
Gareth Davies comes into the starting XV to partner Dan Biggar.
Nick Tompkins and Owen Watkin form a new-look midfield with Liam Williams returning to the side to line-up alongside Louis Rees-Zammit and Leigh Halfpenny.
“We were pleased to kick the tournament off with a victory last weekend and to be heading to Scotland with a win behind us.
“We continue to build and to move forward and it is great to do that from a position of winning.
“It is a quick six-day turnaround this week but we are looking forward to getting back out there.
“We have picked up a couple of injuries but we see it as more of an opportunity for those coming into the side.
“We have to feel extremely disappointed for Josh (Macleod) who we selected to start and to win his first cap only to be ruled out later that day through injury.â€?
Elliot Dee, Rhodri Jones and Leon Brown provide the front-row cover for Wales with Will Rowlands and James Botham completing the forward contingent. Kieran Hardy, Callum Sheedy and Halaholo provide the back-line cover.
WALES TEAM TO PLAY SCOTLAND (SATURDAY FEBRUARY 13, KO 16.45)
1. Wyn Jones (31 Caps)
2. Ken Owens (78 Caps)
3. Tomas Francis (53 Caps)
4. Adam Beard (22 Caps)
5. Alun Wyn Jones (CAPT) (144 Caps)
6. Aaron Wainwright (27 Caps)
7. Justin Tipuric (81 Caps)
8. Taulupe Faletau (82 Caps)
9. Gareth Davies (58 Caps)
10. Dan Biggar (88 Caps)
11. Liam Williams (67 Caps)
12. Nick Tompkins (9 Caps)
13. Owen Watkin (26 Caps)
14. Louis Rees-Zammit (5 Caps)
15. Leigh Halfpenny (94 Caps)
Replacements:
16. Elliot Dee (33 Caps)
17. Rhodri Jones (18 Caps)
18. Leon Brown (13 Caps)
19. Will Rowlands (6 Caps)
20. James Botham (3 Caps)
21. Kieran Hardy (2 Caps)
22. Callum Sheedy (5 Caps)
23. Uilisi Halaholo (*Uncapped)
Players unavailable for selection:
Dan Lydiate (released), Josh Navidi, Josh Macleod, Tomos Williams, Johnny Williams, George North, Jonathan Davies, Hallam Amos, Josh Adams.
