Best leads the team out but it will also be Darren Cave’s final home appearance too if he is used from the bench.
In what will be an emotional day in Belfast, Eric O’Sullivan and Ross Kane partner Best in the front-row with Iain Henderson and Kieran Treadwell packing down in the engine room.
Nick Timoney, Jordi Murphy and Marcell Coetzee are selected at six, seven and eight respectively to finish off the pack.
John Cooney and Billy Burns line-out in the half-backs after being rested last weekend against Leinster. Stuart McCloskey and Luke Marshall are just outside them in the centre.
Rob Lyttle and Robert Baloucoune start on either side of Michael Lowry in the back-three.
There is plenty of experience on the bench with the likes of Rob Herring, Andy Warwick, Sean Reidy and Darren Cave to call upon.
Speaking ahead of the game Best has admitted he couldn’t imagine a better way to sign off in front of the home crowd.
“If I could pick a way to go out, it would be knockout rugby at the stadium that I have played at for such a long time. I supported the team, I played for the team and I hope it will be a great atmosphere. It will be nice to get out there and thank the fans more than anything and all the people who have supported me for 15 years now,” he said.
Connacht are the team looking to rain on the Ulster parade and defeated Ulster on their home soil for the first time in 58 years earlier in the season.
Denis Buckley, Dave Heffernan and Finlay Bealham open the game as the front-three, with Ultan Dillane and Gavin Thornbury starting as the locks.
Eoin McKeon is the blindside flanker, with Colby Fainga’a on openside and captain Jarrad Butler at No 8.
Kieran Marmion has been chosen ahead of Caolin Blade at scrum-half, and Jack Carty at fly-half.
Bundee Aki and Tom Farrell are at 12 and 13 respectively, as Matt Healy, Stephen Fitzgerald and Tiernan O’Halloran make up the starting XV.
There is power on the bench too, especially in the backs as Caolin Blade, Tom Daly and Darragh Leader are all available to the men from the West.
Connacht head coach Andy Friend is delighted that his side have reached their goal of clinching a knock-out spot but believes there is more to come from his men.
“This is a massive game for us. Knock-out rugby with the added incentive of an interpro. We said all season that we wanted to be playing at the business end of the season but now we want to go and win and get to a semi-final. I genuinely feel that we haven’t played our best rugby yet and we are constantly improving,” he said.
The winner of this game will go on to face Glasgow Warriors in Scotstoun for a place in the final and whoever wins this weekend could go all the way.
Check Out the Highlights From When the Two Last Met Below
Ulster name team for Northampton Quarter-Final trip
Michael Lowry is named to start at full-back, and is joined in the back three by Jacob Stockdale and Robert Baloucoune. Stuart McCloskey and James Hume will form the midfield duo, and Billy Burns and John Cooney are the starting half-backs.
In the front row, Eric O’Sullivan, Rob Herring and Marty Moore retain their starting berths. Alan O’Connor will partner Kieran Treadwell in the second row. Last week’s Player of the Match, Sean Reidy, will start at blindside flanker, with Jordi Murphy skippering the team at openside and Nick Timoney at Number Eight.
John Andrew, Andrew Warwick, Tom O’Toole, Matty Rea and Greg Jones will provide the forward reinforcements from the bench, with Alby Mathewson, Ian Madigan and Ethan McIlroy named as the back line options.
Ulster team to play Northampton Saints, Challenge Cup Quarter-Final, Saturday 10 April at Franklin’s Gardens (kick-off 8pm, live on BT Sport):
(15-9) Michael Lowry, Robert Baloucoune, James Hume, Stuart McCloskey, Jacob Stockdale, Billy Burns, John Cooney;
(1-8) Eric O’Sullivan, Rob Herring, Marty Moore, Alan O’Connor, Kieran Treadwell, Sean Reidy, Jordi Murphy (Capt.), Nick Timoney.
Replacements: John Andrew, Andrew Warwick, Tom O’Toole, Matty Rea, Greg Jones, Alby Mathewson, Ian Madigan, Ethan McIlroy.
Big names miss out for Ulster
The back line sees just one change from the side that played Toulouse last Friday. Michael Lowry, Jacob Stockdale and Matt Faddes all retain their positions in the back three. Stuart McCloskey and James Hume are the starting midfield duo. Billy Burns returns at fly-half and will captain the side; he will partner John Cooney at scrum-half.
The front row remains unchanged for this game. Rob Herring is named at hooker, with Eric O’Sullivan and Marty Moore packing down at loosehead and tighthead prop. Alan O’Connor will partner with his brother David – who will make his first Heineken Champions Cup start with Sam Carter missing out through concussion. Sean Reidy has been selected at blindside, with Jordi Murphy returning at openside. Nick Timoney comes in to start at Number Eight to replace the injured Marcel Coetzee.
John Andrew, Kyle McCall, Tom O’Toole, Matty Rea, and Greg Jones are the forward bench options. Academy player, Ethan McIlroy could make his European debut if called upon from the bench, and is named alongside Alby Mathewson and Ian Madigan in the back line replacements.
Ulster team to play Gloucester, Heineken Champions Cup Round 2, Saturday 19 December 2020 at Kingsholm Stadium, kick-off 3.15pm, live on BT Sport / beIN Sport:
(15-9) Michael Lowry, Matt Faddes, James Hume, Stuart McCloskey, Jacob Stockdale, Billy Burns (Capt.), John Cooney;
(1-8) Eric O’Sullivan, Rob Herring, Marty Moore, Alan O’Connor, David O’Connor, Sean Reidy, Jordi Murphy, Nick Timoney.
Replacements: John Andrew, Kyle McCall, Tom O’Toole, Matty Rea, Greg Jones, Alby Mathewson, Ian Madigan, Ethan McIlroy.
Ulster name strong side to face Toulouse
In the back three, Jacob Stockdale returns from international duty to the left wing, joining Michael Lowry at full-back and Matt Faddes on the right wing. In midfield, Stuart McCloskey also returns from the Ireland squad to partner with James Hume. Ian Madigan has been named at fly-half alongside John Cooney at scrum-half.
Having made his international debut against Scotland last week, Eric O’Sullivan, comes in to take the starting berth at loosehead prop. Rob Herring also returns from Ireland duties and is named at hooker, with Marty Moore retaining his position at tighthead. Alan O’Connor will partner with Sam Carter, who will lead the side from the second row. Sean Reidy and Jordi Murphy are named at blindside and openside, with Marcell Coetzee completing the pack at Number Eight.
John Andrew, Andrew Warwick, Tom O’Toole, David O’Connor, and Matty Rea provide the forward options, with Alby Mathewson, Stewart Moore and Craig Gilroy offering back line cover from the bench.
Ulster team to play Toulouse, Heineken Champions Cup Round 1, Friday 11 December 2020 at Kingspan Stadium, kick-off 8pm, live on BT Sport / beIN Sport:
(15-9) Michael Lowry, Matt Faddes, James Hume, Stuart McCloskey, Jacob Stockdale, Ian Madigan, John Cooney;
(1-8) Eric O’Sullivan, Rob Herring, Marty Moore, Alan O’Connor, Sam Carter (Capt.), Sean Reidy, Jordi Murphy, Marcell Coetzee.
Replacements: John Andrew, Andrew Warwick, Tom O’Toole, David O’Connor, Matty Rea, Alby Mathewson, Stewart Moore, Craig Gilroy.